AIDS 1981? to present
Although it pales in comparison to the total deaths caused by influenza, malaria and other epidemic diseases, AIDs is on the list of the worst plagues of all time. Since 1981, 25 million deaths have been attributed to the disease.
Like Malaria, the tragedy is that the deaths are entirely preventable, since AIDS is transmitted, not through the air, or food or water, but through known human behaviors. Daddy was given tainted blood during heart surgery, they did not know what the germ in his blood was. He called it 'dirty blood', it was AIDS.